High-dose oral multivitamins and minerals after heart attack

This study examined a subgroup of the Trial to Assess Chelation Therapy (TACT) (1). It looked at oral multivitamins and minerals after heart attack to see if they improved outcomes and included patients not on statins. There were 460 (27%) of 1,708 TACT participants not taking statins at baseline, 224 (49%) were in the active vitamin group and 236 (51%) were in the placebo group. The intervention was a daily high-dose tablet, 6 per day. The primary end point of TACT was time to the first occurrence of any component of the composite end point: all-cause mortality, MI, stroke, coronary revascularization, or hospitalization for angina. The results showed better outcomes in the vitamin group. The authors conclude that high-dose oral multivitamin and multimineral supplementation seem to decrease combined cardiac events in a stable, post-MI population not taking statin therapy at baseline.